A major application of supramolecular chemistry is the design and understanding of catalysts and catalysis. Noncovalent interactions are extremely important in catalysis, binding reactants into conformations suitable for reaction and lowering the transition state energy of reaction. Template-directed synthesis is a special case of supramolecular catalysis. Encapsulation systems such as micelles and dendrimers are also used in catalysis to create microenvironments suitable for reactions (or steps in reactions) to progress that is not possible to use on a macroscopic scale.
Catalysis is the process by which the rate of a chemical reaction (or biological process) is increased by means of the addition of a species known as a catalyst to the reaction. What makes a catalyst different from a chemical reagent is that whilst it participates in the reaction, is not consumed in the reaction. That is, the catalysts may undergo several chemical transformations during the reaction, but at the conclusion of the reaction, the catalyst is regenerated unchanged. As a catalyst is regenerated in a reaction, often only a very small amount is needed to increase the rate of the reaction.